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The FDA label provides dose-reduction guidance only for strong dual CYP3A4/P-gp inhibitors (reduce to 2.5 mg twice daily) and lists specific contraindicated inducers [1]
Their clinical evidence concerns different interventions and should be assessed separately
Primary osteoblasts deficient in DHCR7 accelerate osteogenic differentiation by upregulating the expression of Col1a1 (osteogenic factor), while INSIG1/2-deficient cells have the opposite effect
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